Compound Detail
CHEMBL446197
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Cc1nc(Cc2nc3cc(-c4nn([C@H]5CC[C@H](N6CCOCC6)CC5)c5ncnc(N)c45)ccc3[nH]2)cs1
Basic Information
| ChEMBL ID | CHEMBL446197 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | STAAEKNKOMTDTG-MXVIHJGJSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
529.7
MW (Da)
4.12
ALogP
10
HBA
2
HBD
123.7
PSA (Ų)
0.35
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.81
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor CHEMBL1957 | IC50 | 5.81 | 5.645 | 1542.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor | IC50 | = | 1542.0 | nM | 5.81 | Inhibition IGF1R phosphorylation in human MiaPaCa2 cells | 17689078 |
| Insulin-like growth factor 1 receptor | IC50 | = | 3310.0 | nM | 5.48 | Inhibition of human IGF1R expressed in Sf21 cells by time-resolved fluorescence ... | 17689078 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17689078 | 10.1016/j.bmcl.2007.07.037 | Insulin-like growth factor 1 receptor | 2 |
Data from ChEMBL 36 via Core Engine