Assay Detail
Binding
CHEMBL941658
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Inhibition IGF1R phosphorylation in human MiaPaCa2 cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MiaPaCa2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrazolo[3,4-d]pyrimidines as potent inhibitors of the insulin-like growth factor receptor (IGF-IR).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.56 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248877 | — | — | 1 | 7.25 |
| CHEMBL249295 | — | — | 1 | 7.24 |
| CHEMBL429299 | — | — | 1 | 7.19 |
| CHEMBL249082 | — | — | 1 | 7.08 |
| CHEMBL251732 | — | — | 1 | 7.05 |
| CHEMBL249496 | — | — | 1 | 7.03 |
| CHEMBL249325 | — | — | 1 | 6.98 |
| CHEMBL250085 | — | — | 1 | 6.95 |
| CHEMBL248698 | — | — | 1 | 6.93 |
| CHEMBL400657 | — | — | 1 | 6.88 |
| CHEMBL251326 | — | — | 1 | 6.85 |
| CHEMBL437584 | — | — | 1 | 6.85 |
| CHEMBL399225 | — | — | 1 | 6.78 |
| CHEMBL438344 | — | — | 1 | 6.74 |
| CHEMBL428414 | — | — | 1 | 6.71 |
| CHEMBL400457 | — | — | 1 | 6.60 |
| CHEMBL251534 | — | — | 1 | 6.59 |
| CHEMBL398916 | — | — | 1 | 6.57 |
| CHEMBL399021 | — | — | 1 | 6.49 |
| CHEMBL249711 | — | — | 1 | 6.43 |
| CHEMBL429664 | — | — | 1 | 6.37 |
| CHEMBL429832 | — | — | 1 | 6.31 |
| CHEMBL400727 | — | — | 1 | 6.20 |
| CHEMBL249296 | — | — | 1 | 6.10 |
| CHEMBL251292 | — | — | 1 | 6.09 |
| CHEMBL437198 | — | — | 1 | 5.90 |
| CHEMBL446197 | — | — | 1 | 5.81 |
| CHEMBL249699 | — | — | 1 | 5.63 |
| CHEMBL400277 | — | — | 1 | 5.58 |
| CHEMBL399224 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248877 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL249295 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL429299 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL249082 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL251732 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL249496 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL249325 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL250085 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL248698 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL400657 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL251326 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL437584 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL399225 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL438344 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL428414 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL400457 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL251534 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL398916 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL399021 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL249711 | — | IC50 | = | 372.0 | nM | 6.43 |
| CHEMBL429664 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL429832 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL400727 | — | IC50 | = | 637.0 | nM | 6.20 |
| CHEMBL249296 | — | IC50 | = | 787.0 | nM | 6.10 |
| CHEMBL251292 | — | IC50 | = | 819.0 | nM | 6.09 |
| CHEMBL437198 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL446197 | — | IC50 | = | 1542.0 | nM | 5.81 |
| CHEMBL249699 | — | IC50 | = | 2335.0 | nM | 5.63 |
| CHEMBL400277 | — | IC50 | = | 2646.0 | nM | 5.58 |
| CHEMBL399224 | — | IC50 | = | 2794.0 | nM | 5.55 |
| CHEMBL398957 | — | IC50 | - | — | - |