Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL4467328

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CC(C)C[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H]1O

Basic Information

ChEMBL ID CHEMBL4467328
Phase Preclinical
Structure Type MOL
InChI Key ZSXZGQLSAQIVTI-XKYXEJCGSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

436.4
MW (Da)
-3.09
ALogP
11
HBA
5
HBD
203.0
PSA (Ų)
0.28
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H24N4O9S
MW 436.44
Aromatic Rings 1
Heavy Atoms 29
NP-Likeness 0.80

Activity Summary

Ki 1 meas. best 7.68

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Leucine--tRNA ligase
CHEMBL4295566
Ki 7.68 7.68 20.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
30995568 10.1016/j.ejmech.2019.04.003 Leucine--tRNA ligase 5
30995568 10.1016/j.ejmech.2019.04.003 Isoleucine--tRNA ligase 3
30995568 10.1016/j.ejmech.2019.04.003 Tyrosine--tRNA ligase 2

Data from ChEMBL 36 via Core Engine