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Compound Detail

CHEMBL4473515

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O=c1ccc2c(C(O)CNCCCc3cccc(O)c3)ccc(O)c2[nH]1

Basic Information

ChEMBL ID CHEMBL4473515
Phase Preclinical
Structure Type MOL
InChI Key KRPZILIWVMUVCF-UHFFFAOYSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

354.4
MW (Da)
2.20
ALogP
5
HBA
5
HBD
105.6
PSA (Ų)
0.42
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H22N2O4
MW 354.41
Aromatic Rings 3
Heavy Atoms 26
NP-Likeness 0.37

Activity Summary

EC50 3 meas. best 10.44

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 10.44 10.44 0.0 2
Beta-1 adrenergic receptor
CHEMBL213
EC50 6.66 6.66 218.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
30392952 10.1016/j.bmc.2018.10.043 Beta-2 adrenergic receptor 8
30392952 10.1016/j.bmc.2018.10.043 Beta-1 adrenergic receptor 1
30392952 10.1016/j.bmc.2018.10.043 Unchecked 1

Data from ChEMBL 36 via Core Engine