Compound Detail
CHEMBL447366
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Basic Information
| ChEMBL ID | CHEMBL447366 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QZQMHVURPDKZHO-WHFBIAKZSA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
218.0
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.08
IC50 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 CHEMBL284 | Ki | 8.08 | 8.08 | 8.3 | 1 |
| Dipeptidyl peptidase 8 CHEMBL4657 | Ki | 6.06 | 6.06 | 880.0 | 1 |
| Dipeptidyl peptidase 9 CHEMBL4793 | Ki | 5.68 | 5.68 | 2100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 | Ki | = | 8.3 | nM | 8.08 | Inhibition of human placental DPP4 | 18783201 |
| Dipeptidyl peptidase 8 | Ki | = | 880.0 | nM | 6.06 | Inhibition of human recombinant DPP8 expressed in HEK293T cells | 18783201 |
| Dipeptidyl peptidase 9 | Ki | = | 2100.0 | nM | 5.68 | Inhibition of human recombinant DPP9 expressed in HEK293T cells | 18783201 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18783201 | 10.1021/jm800390n | Dipeptidyl peptidase 9 | 9 |
| 18783201 | 10.1021/jm800390n | Rattus norvegicus | 4 |
| 18783201 | 10.1021/jm800390n | Mus musculus | 3 |
| 18783201 | 10.1021/jm800390n | Dipeptidyl peptidase 4 | 2 |
| 18783201 | 10.1021/jm800390n | Unchecked | 2 |
| 18783201 | 10.1021/jm800390n | Dipeptidyl peptidase 8 | 1 |
| 18783201 | 10.1021/jm800390n | ADMET | 1 |
Data from ChEMBL 36 via Core Engine