Assay Detail
Binding
CHEMBL1035669
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Inhibition of human recombinant DPP9 expressed in HEK293T cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.66 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67089 | — | — | 1 | 9.39 |
| CHEMBL63860 | — | — | 1 | 9.28 |
| CHEMBL67279 | TALABOSTAT | 3.0 | 1 | 9.12 |
| CHEMBL494497 | — | — | 1 | 8.59 |
| CHEMBL365322 | — | — | 1 | 7.30 |
| CHEMBL501506 | — | — | 1 | 6.58 |
| CHEMBL447366 | — | — | 1 | 5.68 |
| CHEMBL460984 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67089 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL63860 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL67279 | TALABOSTAT | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL494497 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL365322 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL501506 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL447366 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL460984 | — | Ki | = | 4300.0 | nM | 5.37 |