Compound Detail
CHEMBL460984
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Basic Information
| ChEMBL ID | CHEMBL460984 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MSUFTSQCNKNUBM-UWVGGRQHSA-N |
3
Targets
3
Activities
1
Assay Types
1
PK Parameters
5
Publications
0
Known Names
Molecular Properties
256.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 5.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 CHEMBL284 | Ki | 5.48 | 5.48 | 3300.0 | 1 |
| Dipeptidyl peptidase 9 CHEMBL4793 | Ki | 5.37 | 5.37 | 4300.0 | 1 |
| Dipeptidyl peptidase 8 CHEMBL4657 | Ki | 5.08 | 5.08 | 8400.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.5 | hr | - |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 | Ki | = | 3300.0 | nM | 5.48 | Inhibition of human placental DPP4 | 18783201 |
| Dipeptidyl peptidase 9 | Ki | = | 4300.0 | nM | 5.37 | Inhibition of human recombinant DPP9 expressed in HEK293T cells | 18783201 |
| Dipeptidyl peptidase 8 | Ki | = | 8400.0 | nM | 5.08 | Inhibition of human recombinant DPP8 expressed in HEK293T cells | 18783201 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18783201 | 10.1021/jm800390n | Unchecked | 2 |
| 18783201 | 10.1021/jm800390n | Dipeptidyl peptidase 4 | 1 |
| 18783201 | 10.1021/jm800390n | Dipeptidyl peptidase 8 | 1 |
| 18783201 | 10.1021/jm800390n | Dipeptidyl peptidase 9 | 1 |
| 21388136 | 10.1021/jm100972f | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine