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Compound Detail

CHEMBL4513604

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COc1c(C(C)C)cc2c(c1O)[C@]13CCC[C@](C)([C@H](OC(C)=O)OC1=O)[C@@H]3CC2

Basic Information

ChEMBL ID CHEMBL4513604
Phase Preclinical
Structure Type MOL
InChI Key UNQVCHJFBNMSGB-AZIXLERZSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

402.5
MW (Da)
3.96
ALogP
6
HBA
1
HBD
82.1
PSA (Ų)
0.77
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C23H30O6
MW 402.49
Aromatic Rings 1
Heavy Atoms 29
NP-Likeness 2.36

Activity Summary

IC50 2 meas. best 4.46

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Entamoeba histolytica
CHEMBL612853
IC50 4.46 4.46 34900.0 1
Giardia intestinalis
CHEMBL612652
IC50 4.33 4.33 46400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
31063376 10.1021/acs.jnatprod.8b00952 Brain 1
31063376 10.1021/acs.jnatprod.8b00952 No relevant target 1
31063376 10.1021/acs.jnatprod.8b00952 Entamoeba histolytica 1
31063376 10.1021/acs.jnatprod.8b00952 Giardia intestinalis 1
31063376 10.1021/acs.jnatprod.8b00952 Rattus norvegicus 1

Data from ChEMBL 36 via Core Engine