Assay Detail
Functional
CHEMBL4321734
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Antiparasitic activity against Entamoeba histolytica HM1-IMSS trophozoites assessed as inhibition of parasitic growth treated for 48 hrs followed by compound washout and measured after 48 hrs by MTT/PMS dye based colorimetric method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Entamoeba histolytica |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure and Absolute Configuration of Abietane Diterpenoids from Salvia clinopodioides: Antioxidant, Antiprotozoal, and Antipropulsive Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.85 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | 6.70 |
| CHEMBL50588 | EMETINE | 4.0 | 1 | 5.66 |
| CHEMBL4472179 | — | — | 1 | 4.50 |
| CHEMBL4513604 | — | — | 1 | 4.46 |
| CHEMBL4447242 | — | — | 1 | 4.42 |
| CHEMBL4593114 | — | — | 1 | 4.40 |
| CHEMBL4449934 | — | — | 1 | 4.37 |
| CHEMBL4572137 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137 | METRONIDAZOLE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL50588 | EMETINE | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4472179 | — | IC50 | = | 31300.0 | nM | 4.50 |
| CHEMBL4513604 | — | IC50 | = | 34900.0 | nM | 4.46 |
| CHEMBL4447242 | — | IC50 | = | 37800.0 | nM | 4.42 |
| CHEMBL4593114 | — | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL4449934 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4572137 | — | IC50 | = | 48500.0 | nM | 4.31 |