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Compound Detail

CHEMBL4593114

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CC(=O)Oc1c(C(C)C)cc2c(c1OC(C)=O)[C@]13CCC[C@](C)([C@H](OC(C)=O)OC1=O)[C@@H]3CC2

Basic Information

ChEMBL ID CHEMBL4593114
Phase Preclinical
Structure Type MOL
InChI Key GZGKESJGKMIWGR-QNMIOERPSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

472.5
MW (Da)
4.10
ALogP
8
HBA
0
HBD
105.2
PSA (Ų)
0.48
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C26H32O8
MW 472.53
Aromatic Rings 1
Heavy Atoms 34
NP-Likeness 1.90

Activity Summary

IC50 2 meas. best 4.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Entamoeba histolytica
CHEMBL612853
IC50 4.4 4.4 39500.0 1
Giardia intestinalis
CHEMBL612652
IC50 4.32 4.32 47700.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
31063376 10.1021/acs.jnatprod.8b00952 Brain 1
31063376 10.1021/acs.jnatprod.8b00952 No relevant target 1
31063376 10.1021/acs.jnatprod.8b00952 Entamoeba histolytica 1
31063376 10.1021/acs.jnatprod.8b00952 Giardia intestinalis 1
31063376 10.1021/acs.jnatprod.8b00952 Rattus norvegicus 1

Data from ChEMBL 36 via Core Engine