Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL4447242

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CC(C)c1cc2c(c(O)c1O)[C@]13CCC[C@](C)([C@H](O)OC1=O)[C@@H]3CC2

Basic Information

ChEMBL ID CHEMBL4447242
Phase Preclinical
Structure Type MOL
InChI Key UJSRRPXGXDAPTC-YXHXOZEPSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

346.4
MW (Da)
3.09
ALogP
5
HBA
3
HBD
87.0
PSA (Ų)
0.54
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C20H26O5
MW 346.42
Aromatic Rings 1
Heavy Atoms 25
NP-Likeness 2.31

Activity Summary

IC50 4 meas. best 5.23

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Brain
CHEMBL613617
IC50 5.23 5.23 5900.0 1
No relevant target
CHEMBL2362975
IC50 4.61 4.61 24800.0 1
Entamoeba histolytica
CHEMBL612853
IC50 4.42 4.42 37800.0 1
Giardia intestinalis
CHEMBL612652
IC50 4.2 4.2 63000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
31063376 10.1021/acs.jnatprod.8b00952 Brain 3
31063376 10.1021/acs.jnatprod.8b00952 No relevant target 1
31063376 10.1021/acs.jnatprod.8b00952 Entamoeba histolytica 1
31063376 10.1021/acs.jnatprod.8b00952 Giardia intestinalis 1
31063376 10.1021/acs.jnatprod.8b00952 Rattus norvegicus 1

Data from ChEMBL 36 via Core Engine