Compound Detail
CHEMBL4519811
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Basic Information
| ChEMBL ID | CHEMBL4519811 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FACYQMLOTXHWDQ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
507.7
MW (Da)
2.97
ALogP
8
HBA
3
HBD
108.6
PSA (Ų)
0.52
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase receptor UFO CHEMBL4895 | IC50 | 8.35 | 8.35 | 4.5 | 1 |
| TEL/AXL CHEMBL4523666 | IC50 | 6.67 | 6.67 | 213.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase receptor UFO | IC50 | = | 4.5 | nM | 8.35 | Inhibition of AXL (unknown origin) using poly (Glu, Tyr) as substrate after 60 m... | 30685094 |
| TEL/AXL | IC50 | = | 213.9 | nM | 6.67 | Inhibition of TEL/AXL (unknown origin) expressed in mouse BA/F3 cells assessed a... | 30685094 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30685094 | 10.1016/j.bmcl.2019.01.018 | Tyrosine-protein kinase receptor UFO | 1 |
| 30685094 | 10.1016/j.bmcl.2019.01.018 | TEL/AXL | 1 |
Data from ChEMBL 36 via Core Engine