Compound Detail
CHEMBL4520801
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C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccc(Cl)cc4)cc3)c(C(N)=O)c2N)C1
Basic Information
| ChEMBL ID | CHEMBL4520801 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HOUMQZGBNXSVNG-QGZVFWFLSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
465.9
MW (Da)
4.03
ALogP
6
HBA
2
HBD
116.5
PSA (Ų)
0.53
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 9.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase BTK CHEMBL5251 | IC50 | 9.77 | 9.755 | 0.2 | 2 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 8.1 | 7.96 | 7.9 | 2 |
| Proto-oncogene tyrosine-protein kinase Src CHEMBL267 | IC50 | 7.14 | 7.14 | 72.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase BTK | IC50 | = | 0.17 | nM | 9.77 | Human BTK LanthaScreen Assay: TR-FRET LanthaScreen assays were performed by incu... | - |
| Tyrosine-protein kinase BTK | IC50 | = | 0.18 | nM | 9.74 | Inhibition of full-length human His-tagged BTK expressed in baculovirus expressi... | 30655951 |
| Epidermal growth factor receptor | IC50 | = | 7.9 | nM | 8.1 | Human EGFR LanthaScreen Selectivity Assay: TR-FRET LanthaScreen assays were perf... | - |
| Epidermal growth factor receptor | IC50 | = | 15.0 | nM | 7.82 | Inhibition of human EGFR cytoplasmic domain expressed in baculovirus expression ... | 30655951 |
| Proto-oncogene tyrosine-protein kinase Src | IC50 | = | 72.0 | nM | 7.14 | Inhibition of full-length recombinant human C-terminal His-tagged SRC cytoplasmi... | 30655951 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30655951 | 10.1021/acsmedchemlett.8b00461 | Tyrosine-protein kinase BTK | 1 |
| 30655951 | 10.1021/acsmedchemlett.8b00461 | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 30655951 | 10.1021/acsmedchemlett.8b00461 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine