Compound Detail
CHEMBL4524697
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Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccc2c(-c3cnn(C)c3)n[nH]c2c1
Basic Information
| ChEMBL ID | CHEMBL4524697 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YDNKVGSHYQPIMR-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
6
PK Parameters
5
Publications
0
Known Names
Molecular Properties
475.5
MW (Da)
6.21
ALogP
4
HBA
2
HBD
75.6
PSA (Ų)
0.32
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Discoidin domain-containing receptor 2 CHEMBL5122 | IC50 | 8.36 | 8.36 | 4.4 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.19 | 8.19 | 6.4 | 1 |
| NCI-H2286 CHEMBL4483261 | IC50 | 7.61 | 7.61 | 24.3 | 1 |
| KG-1 CHEMBL612264 | IC50 | 7.18 | 7.18 | 65.7 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 3475.0 | ng.hr.mL-1 | Mus musculus |
| AUC | 3485.0 | ng.hr.mL-1 | Mus musculus |
| Cmax | 1871.83 | nM | Mus musculus |
| MRT | 3.26 | hr | Mus musculus |
| T1/2 | 2.75 | hr | Mus musculus |
| Tmax | 1.17 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Discoidin domain-containing receptor 2 | IC50 | = | 4.4 | nM | 8.36 | Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60... | 30572178 |
| Fibroblast growth factor receptor 1 | IC50 | = | 6.4 | nM | 8.19 | Inhibition of FGFR1 (unknown origin) after 60 mins by ELISA | 30572178 |
| NCI-H2286 | IC50 | = | 24.3 | nM | 7.61 | Antiproliferative activity against human NCI-H2286 cells after 72 hrs by CCK8 as... | 30572178 |
| KG-1 | IC50 | = | 65.7 | nM | 7.18 | Antiproliferative activity against human KG1 cells after 72 hrs by CCK8 assay | 30572178 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30572178 | 10.1016/j.ejmech.2018.12.015 | ADMET | 6 |
| 30572178 | 10.1016/j.ejmech.2018.12.015 | KG-1 | 1 |
| 30572178 | 10.1016/j.ejmech.2018.12.015 | Fibroblast growth factor receptor 1 | 1 |
| 30572178 | 10.1016/j.ejmech.2018.12.015 | Discoidin domain-containing receptor 2 | 1 |
| 30572178 | 10.1016/j.ejmech.2018.12.015 | NCI-H2286 | 1 |
Data from ChEMBL 36 via Core Engine