Compound Detail
CHEMBL456660
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL456660 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GDLJPDYHXFKVAI-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
413.5
MW (Da)
3.23
ALogP
6
HBA
1
HBD
90.1
PSA (Ų)
0.71
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 CHEMBL1800 | IC50 | 7.3 | 7.3 | 50.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 | IC50 | = | 50.12 | nM | 7.3 | Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed i... | 18989952 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18989952 | 10.1021/jm800744m | Corticotropin-releasing factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine