Assay Detail
Binding
CHEMBL1004666
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Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and pharmacological characterization of novel druglike corticotropin-releasing factor 1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.77 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL309138 | — | — | 1 | 7.55 |
| CHEMBL458810 | — | — | 1 | 7.49 |
| CHEMBL44698 | — | — | 1 | 7.40 |
| CHEMBL456660 | — | — | 1 | 7.30 |
| CHEMBL459173 | — | — | 1 | 7.25 |
| CHEMBL514270 | EMICERFONT | 2.0 | 1 | 7.18 |
| CHEMBL516170 | — | — | 1 | 7.17 |
| CHEMBL456640 | — | — | 1 | 7.17 |
| CHEMBL464185 | — | — | 1 | 7.05 |
| CHEMBL515363 | — | — | 1 | 6.92 |
| CHEMBL513937 | — | — | 1 | 6.92 |
| CHEMBL458599 | — | — | 1 | 6.91 |
| CHEMBL456448 | — | — | 1 | 6.84 |
| CHEMBL464184 | — | — | 1 | 6.80 |
| CHEMBL456449 | — | — | 1 | 6.51 |
| CHEMBL457710 | — | — | 1 | 6.50 |
| CHEMBL457742 | — | — | 1 | 6.44 |
| CHEMBL458626 | — | — | 1 | 6.43 |
| CHEMBL515532 | — | — | 1 | 6.10 |
| CHEMBL457975 | — | — | 1 | 5.91 |
| CHEMBL458600 | — | — | 1 | 5.71 |
| CHEMBL515503 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL309138 | — | IC50 | = | 28.18 | nM | 7.55 |
| CHEMBL458810 | — | IC50 | = | 32.36 | nM | 7.49 |
| CHEMBL44698 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL456660 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL459173 | — | IC50 | = | 56.23 | nM | 7.25 |
| CHEMBL514270 | EMICERFONT | IC50 | = | 66.07 | nM | 7.18 |
| CHEMBL516170 | — | IC50 | = | 67.61 | nM | 7.17 |
| CHEMBL456640 | — | IC50 | = | 67.61 | nM | 7.17 |
| CHEMBL464185 | — | IC50 | = | 89.13 | nM | 7.05 |
| CHEMBL515363 | — | IC50 | = | 120.23 | nM | 6.92 |
| CHEMBL513937 | — | IC50 | = | 120.23 | nM | 6.92 |
| CHEMBL458599 | — | IC50 | = | 123.03 | nM | 6.91 |
| CHEMBL456448 | — | IC50 | = | 144.54 | nM | 6.84 |
| CHEMBL464184 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL456449 | — | IC50 | = | 309.03 | nM | 6.51 |
| CHEMBL457710 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL457742 | — | IC50 | = | 363.08 | nM | 6.44 |
| CHEMBL458626 | — | IC50 | = | 371.54 | nM | 6.43 |
| CHEMBL515532 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL457975 | — | IC50 | = | 1230.27 | nM | 5.91 |
| CHEMBL458600 | — | IC50 | = | 1949.84 | nM | 5.71 |
| CHEMBL515503 | — | IC50 | = | 3235.94 | nM | 5.49 |