Compound Detail
CHEMBL514270
EMICERFONT 🧪 Phase II
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL514270 |
| Name | EMICERFONT |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | JFHJGXQFESYQGY-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
6
PK Parameters
6
Publications
5
Known Names
2
Indications
1
Mechanisms
Molecular Properties
404.5
MW (Da)
3.12
ALogP
6
HBA
1
HBD
75.5
PSA (Ų)
0.72
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Corticotropin releasing factor receptor 1 antagonist | ANTAGONIST | Corticotropin-releasing factor receptor 1 | ✓ | ✓ |
Indications
Irritable Bowel Syndrome Phobia, Social
Activity Summary
IC50 1 meas. best 7.18
Kd 1 meas. best 7.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 CHEMBL1800 | IC50 | 7.18 | 7.18 | 66.1 | 1 |
| Corticotropin-releasing factor receptor 1 CHEMBL1800 | Kd | 7.14 | 7.14 | 72.4 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 19.0 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 16.0 | mL.min-1.kg-1 | Callithrix jacchus |
| F | 66.0 | % | Rattus norvegicus |
| F | 65.0 | % | Callithrix jacchus |
| T1/2 | 1.6 | hr | Rattus norvegicus |
| T1/2 | 3.7 | hr | Callithrix jacchus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 | IC50 | = | 66.07 | nM | 7.18 | Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed i... | 18989952 |
| Corticotropin-releasing factor receptor 1 | Kd | = | 72.44 | nM | 7.14 | Antagonist activity at human CRF1 receptor expressed in CHO cells assessed as ef... | 18989952 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18989952 | 10.1021/jm800744m | Callithrix jacchus | 6 |
| 18989952 | 10.1021/jm800744m | Rattus norvegicus | 5 |
| 18989952 | 10.1021/jm800744m | Meriones unguiculatus | 4 |
| 18989952 | 10.1021/jm800744m | Corticotropin-releasing factor receptor 1 | 3 |
| 18989952 | 10.1021/jm800744m | ADMET | 2 |
| 18989952 | 10.1021/jm800744m | Corticotropin-releasing factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine