Compound Detail
CHEMBL4566674
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Basic Information
| ChEMBL ID | CHEMBL4566674 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GJWKEGLNAJZVPI-UHFFFAOYSA-N |
| Parent Compound | CHEMBL4159041 |
| Active Moiety | CHEMBL4159041 |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
432.5
MW (Da)
2.24
ALogP
7
HBA
3
HBD
96.2
PSA (Ų)
0.57
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 28 CHEMBL2157853 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
| Ubiquitin carboxyl-terminal hydrolase 25 CHEMBL4295975 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 28 | IC50 | = | 2000.0 | nM | 5.7 | Inhibition of TEV-cleavable hexa-histidine tagged USP28 (1 to 1077 residues) (un... | - |
| Ubiquitin carboxyl-terminal hydrolase 25 | IC50 | = | 2000.0 | nM | 5.7 | Inhibition of recombinant C-terminal 6-His tagged human USP25 using ubiquitin-rh... | - |
Data from ChEMBL 36 via Core Engine