Compound Detail
CHEMBL45686
PANAMESINE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL45686 |
| Name | PANAMESINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | NINYZUDVKTUKIA-IBGZPJMESA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
1
Known Names
Molecular Properties
426.5
MW (Da)
2.73
ALogP
7
HBA
1
HBD
80.7
PSA (Ų)
0.79
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
Ki 1 meas. best 7.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | Ki | 7.72 | 7.72 | 19.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 | Ki | = | 19.0 | nM | 7.72 | Binding affinity against the sigma receptor from guinea pig brain using the radi... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(01)80443-1 | Sigma non-opioid intracellular receptor 1 | 1 |
| - | 10.6019/CHEMBL5441142 | Schistosoma mansoni | 1 |
Data from ChEMBL 36 via Core Engine