Assay Detail
Binding
CHEMBL804962
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against the sigma receptor from guinea pig brain using the radioligand [3H]SKF-10047
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
(5S)-3-aryl-5-(1-piperidinylmethyl)-2-oxazolidinones, a new class of potential neuroleptics with a high affinity for sigma receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 7.54 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45535 | — | — | 1 | 9.00 |
| CHEMBL417353 | — | — | 1 | 8.70 |
| CHEMBL47715 | — | — | 1 | 8.52 |
| CHEMBL47774 | — | — | 1 | 8.30 |
| CHEMBL47714 | — | — | 1 | 7.92 |
| CHEMBL50771 | — | — | 1 | 7.82 |
| CHEMBL417181 | — | — | 1 | 7.82 |
| CHEMBL48075 | — | — | 1 | 7.80 |
| CHEMBL296504 | — | — | 1 | 7.80 |
| CHEMBL295891 | — | — | 1 | 7.77 |
| CHEMBL46438 | — | — | 1 | 7.75 |
| CHEMBL45686 | PANAMESINE | 2.0 | 1 | 7.72 |
| CHEMBL298492 | — | — | 1 | 7.72 |
| CHEMBL48124 | — | — | 1 | 7.72 |
| CHEMBL45968 | — | — | 1 | 7.62 |
| CHEMBL47678 | — | — | 1 | 7.51 |
| CHEMBL297634 | — | — | 1 | 7.47 |
| CHEMBL22242 | REMOXIPRIDE | 4.0 | 1 | 7.26 |
| CHEMBL47279 | — | — | 1 | 7.21 |
| CHEMBL60859 | BMY-14802 | — | 1 | 7.15 |
| CHEMBL46496 | — | — | 1 | 6.92 |
| CHEMBL289645 | — | — | 1 | 6.77 |
| CHEMBL47834 | — | — | 1 | 6.60 |
| CHEMBL46169 | — | — | 1 | 6.57 |
| CHEMBL43783 | — | — | 1 | 6.52 |
| CHEMBL275707 | RIMCAZOLE | 2.0 | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45535 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL417353 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL47715 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL47774 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL47714 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL50771 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL417181 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL48075 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL296504 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL295891 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL46438 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL45686 | PANAMESINE | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL298492 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL48124 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL45968 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL47678 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL297634 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL22242 | REMOXIPRIDE | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL47279 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL60859 | BMY-14802 | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL46496 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL289645 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL47834 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL46169 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL43783 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL275707 | RIMCAZOLE | Ki | = | 680.0 | nM | 6.17 |