Compound Detail
CHEMBL4581972
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4581972 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MPWQARZLUHZHMX-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
450.6
MW (Da)
3.04
ALogP
7
HBA
3
HBD
105.4
PSA (Ų)
0.60
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| TEL/AXL CHEMBL4523666 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
| Tyrosine-protein kinase receptor UFO CHEMBL4895 | IC50 | 8.08 | 8.08 | 8.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| TEL/AXL | IC50 | = | 3.0 | nM | 8.52 | Inhibition of TEL/AXL (unknown origin) expressed in mouse BA/F3 cells assessed a... | 30685094 |
| Tyrosine-protein kinase receptor UFO | IC50 | = | 8.3 | nM | 8.08 | Inhibition of AXL (unknown origin) using poly (Glu, Tyr) as substrate after 60 m... | 30685094 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30685094 | 10.1016/j.bmcl.2019.01.018 | Tyrosine-protein kinase receptor UFO | 1 |
| 30685094 | 10.1016/j.bmcl.2019.01.018 | TEL/AXL | 1 |
Data from ChEMBL 36 via Core Engine