Compound Detail

CHEMBL4594382

DEURUXOLITINIB PHOSPHATE

💊 Approved Drug

Enter ChEMBL ID:

Free Research Context This compound will appear in recent viewed items on the research home for this browser.

Research home View demo workspace

💊 Approved Drug

O=P(O)(O)O.[2H]C1([2H])C([C@@H](CC#N)n2cc(-c3ncnc4[nH]ccc34)cn2)C([2H])([2H])C([2H])([2H])C1([2H])[2H]

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL4594382
Name	DEURUXOLITINIB PHOSPHATE
Phase	Approved
Structure Type	MOL
InChI Key	JFMWPOCYMYGEDM-NTVOUFPTSA-N
Therapeutic	✓ Yes
Parent Compound	CHEMBL1789941
Active Moiety	CHEMBL1789941

Known Names

C-21543 phosphate CTP-543 phosphate D8- ruxolitinib phosphate D8-ruxolitinib phosphate Deuruxolitinib phosphate Leqselvi

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Mechanisms

Molecular Properties

306.4

MW (Da)

3.47

ALogP

HBA

HBD

83.2

PSA (Å²)

0.80

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
First Approval	2024
Availability	Prescription
Chirality	Single Enantiomer

Routes of Administration

Oral

Flags

Black Box Warning

USAN Stem	deu-; -tinib
USAN Year	2020

Extended Properties

Molecular Formula	C17H21N6O4P
MW	412.42
Aromatic Rings	3
Heavy Atoms	23
NP-Likeness	-0.90

Mechanism of Action

Mechanism	Action Type	Target	Direct	Efficacy
Tyrosine-protein kinase JAK3 inhibitor	INHIBITOR	Tyrosine-protein kinase JAK3	✓	✓
Tyrosine-protein kinase JAK2 inhibitor	INHIBITOR	Tyrosine-protein kinase JAK2	✓	✓
Tyrosine-protein kinase JAK1 inhibitor	INHIBITOR	Tyrosine-protein kinase JAK1	✓	✓
Tyrosine-protein kinase TYK2 inhibitor	INHIBITOR	Non-receptor tyrosine-protein kinase TYK2	✓	✓

Indications

Alopecia Areata

Drug Warnings

Black Box Warning

General Warning

Country: United States

Data from ChEMBL 36 via Core Engine