Compound Detail
CHEMBL461716
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Basic Information
| ChEMBL ID | CHEMBL461716 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LCCYGVBXMXVHRW-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
367.5
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 2 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit alpha-5 CHEMBL5112 | Kd | 8.3 | 8.3 | 5.0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 CHEMBL1962 | Kd | 6.92 | 6.92 | 121.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit alpha-5 | Kd | = | 5.0 | nM | 8.3 | Binding affinity to GABAA alpha-5-beta-2-gamma-2 receptor | 18537233 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Kd | = | 121.0 | nM | 6.92 | Binding affinity to GABAA alpha-1-beta-2-gamma-2 receptor | 18537233 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18537233 | 10.1021/jm701433b | Gamma-aminobutyric acid receptor subunit alpha-1 | 1 |
| 18537233 | 10.1021/jm701433b | Gamma-aminobutyric acid receptor subunit alpha-5 | 1 |
Data from ChEMBL 36 via Core Engine