Compound Detail
CHEMBL463010
MAKALUVIC ACID A Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL463010 |
| Name | MAKALUVIC ACID A |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PTBJVLGXDFOMFM-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
194.2
MW (Da)
0.34
ALogP
2
HBA
2
HBD
73.4
PSA (Ų)
0.68
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| HCT-116 CHEMBL394 | IC50 | 4.55 | 4.55 | 28399.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| HCT-116 | IC50 | = | 28399.0 | nM | 4.55 | Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay | 15332840 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8946754 | 10.1021/np9604947 | P388 | 1 |
| 15332840 | 10.1021/np034084b | HCT-116 | 1 |
Data from ChEMBL 36 via Core Engine