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Assay Detail

CHEMBL1000096

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

Cytotoxic pyrroloiminoquinones from four new species of South African latrunculid sponges.
Antunes EM, Beukes DR, Kelly M, Samaai T, Barrows LR, Marshall KM, Sincich C, Davies-Coleman MT.
J Nat Prod (2004) 67 : 1268 -1276
PubMed 15332840 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.12 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL488771 DISCORHABDINE A 1 8.15
CHEMBL450115 1 7.11
CHEMBL558630 1 6.92
CHEMBL517755 1 6.71
CHEMBL455888 1 6.65
CHEMBL505068 1 6.63
CHEMBL447553 DIHYDRODISCORHABDIN C 1 6.49
CHEMBL464379 DISCORHABDIN G 1 6.49
CHEMBL540660 DISCORHABDIN D 1 6.22
CHEMBL464377 1 6.19
CHEMBL540397 MAKALUVAMINE C 1 5.96
CHEMBL509255 DISCORHABDIN V 1 5.90
CHEMBL457826 TSITSIKAMMAMINE A 1 5.85
CHEMBL541416 DISCORHABDIN N 1 5.65
CHEMBL514900 TSITSIKAMMAMINE B 1 5.62
CHEMBL462951 DAMIRONE B 1 5.51
CHEMBL558429 1 4.90
CHEMBL2448602 1 4.78
CHEMBL463010 MAKALUVIC ACID A 1 4.55
CHEMBL541414 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL488771 DISCORHABDINE A IC50 = 7.0 nM 8.15
CHEMBL450115 IC50 = 77.0 nM 7.11
CHEMBL558630 IC50 = 119.0 nM 6.92
CHEMBL517755 IC50 = 197.0 nM 6.71
CHEMBL455888 IC50 = 222.0 nM 6.65
CHEMBL505068 IC50 = 232.0 nM 6.63
CHEMBL447553 DIHYDRODISCORHABDIN C IC50 = 323.0 nM 6.49
CHEMBL464379 DISCORHABDIN G IC50 = 327.0 nM 6.49
CHEMBL540660 DISCORHABDIN D IC50 = 595.0 nM 6.22
CHEMBL464377 IC50 = 645.0 nM 6.19
CHEMBL540397 MAKALUVAMINE C IC50 = 1089.0 nM 5.96
CHEMBL509255 DISCORHABDIN V IC50 = 1266.0 nM 5.90
CHEMBL457826 TSITSIKAMMAMINE A IC50 = 1414.0 nM 5.85
CHEMBL541416 DISCORHABDIN N IC50 = 2249.0 nM 5.65
CHEMBL514900 TSITSIKAMMAMINE B IC50 = 2382.0 nM 5.62
CHEMBL462951 DAMIRONE B IC50 = 3102.0 nM 5.51
CHEMBL558429 IC50 = 12496.0 nM 4.90
CHEMBL2448602 IC50 = 16541.0 nM 4.78
CHEMBL463010 MAKALUVIC ACID A IC50 = 28399.0 nM 4.55
CHEMBL541414 IC50 = 128213.0 nM -