Compound Detail
CHEMBL463126
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Basic Information
| ChEMBL ID | CHEMBL463126 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KYQWCQJWDVPXKY-GQCTYLIASA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
312.4
MW (Da)
4.19
ALogP
4
HBA
4
HBD
80.9
PSA (Ų)
0.50
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.39
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prostaglandin G/H synthase 1 CHEMBL221 | IC50 | 5.39 | 5.39 | 4100.0 | 1 |
| Prostaglandin G/H synthase 2 CHEMBL230 | IC50 | 4.43 | 4.43 | 36700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 1 | IC50 | = | 4100.0 | nM | 5.39 | Inhibition of COX1 | 11858749 |
| Prostaglandin G/H synthase 2 | IC50 | = | 36700.0 | nM | 4.43 | Inhibition of COX2 | 11858749 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11858749 | 10.1021/np010451c | Unchecked | 1 |
| 11858749 | 10.1021/np010451c | Prostaglandin G/H synthase 1 | 1 |
| 11858749 | 10.1021/np010451c | Prostaglandin G/H synthase 2 | 1 |
Data from ChEMBL 36 via Core Engine