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Assay Detail

CHEMBL1020815

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Binding
Inhibition of COX1
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Prostaglandin G/H synthase 1 (CHEMBL221)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity.
Su BN, Cuendet M, Hawthorne ME, Kardono LB, Riswan S, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD.
J Nat Prod (2002) 65 : 163 -169
PubMed 11858749 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.22 6.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL446319 1 6.32
CHEMBL512578 MORACIN M 1 6.30
CHEMBL457145 1 6.21
CHEMBL165 RESVERATROL 3.0 1 5.96
CHEMBL43065 OXYRESVERATROL 1 5.85
CHEMBL463126 1 5.39
CHEMBL463125 1 5.31
CHEMBL465194 STEPPOGENIN 1 5.23
CHEMBL159303 EPIAFZELECHIN (2R,3R)(-) 1 5.19
CHEMBL517149 1 5.08
CHEMBL517334 ISOGEMICHALCONE B 1 4.93
CHEMBL497716 GEMICHALCONE B 1 4.85
CHEMBL463145 NORARTOCARPETIN 1 4.85
CHEMBL282093 1 4.50
CHEMBL311498 CIANIDANOL 4.0 1 4.43
CHEMBL463453 DIHYDROMORIN 1 4.17
CHEMBL447023 1 4.11
CHEMBL501943 DADAHOL A 1 -
CHEMBL455027 DADAHOL B 1 -
CHEMBL517484 ENGELETIN 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL446319 IC50 = 480.0 nM 6.32
CHEMBL512578 MORACIN M IC50 = 500.0 nM 6.30
CHEMBL457145 IC50 = 610.0 nM 6.21
CHEMBL165 RESVERATROL IC50 = 1100.0 nM 5.96
CHEMBL43065 OXYRESVERATROL IC50 = 1400.0 nM 5.85
CHEMBL463126 IC50 = 4100.0 nM 5.39
CHEMBL463125 IC50 = 4900.0 nM 5.31
CHEMBL465194 STEPPOGENIN IC50 = 5900.0 nM 5.23
CHEMBL159303 EPIAFZELECHIN (2R,3R)(-) IC50 = 6400.0 nM 5.19
CHEMBL517149 IC50 = 8300.0 nM 5.08
CHEMBL517334 ISOGEMICHALCONE B IC50 = 11700.0 nM 4.93
CHEMBL497716 GEMICHALCONE B IC50 = 14000.0 nM 4.85
CHEMBL463145 NORARTOCARPETIN IC50 = 14000.0 nM 4.85
CHEMBL282093 IC50 = 31400.0 nM 4.50
CHEMBL311498 CIANIDANOL IC50 = 36700.0 nM 4.43
CHEMBL463453 DIHYDROMORIN IC50 = 67100.0 nM 4.17
CHEMBL447023 IC50 = 78000.0 nM 4.11
CHEMBL501943 DADAHOL A IC50 > 100.0 ug.mL-1 -
CHEMBL455027 DADAHOL B IC50 > 100.0 ug.mL-1 -
CHEMBL517484 ENGELETIN IC50 > 100.0 ug.mL-1 -