Compound Detail
CHEMBL4637487
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Cc1cn(-c2cc(CN3CCC[C@H](N)C3)cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5ccc(F)cc5)n4)c3)c2)cn1
Basic Information
| ChEMBL ID | CHEMBL4637487 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FSWBQPGSMBLQBY-NDEPHWFRSA-N |
3
Targets
3
Activities
1
Assay Types
5
PK Parameters
6
Publications
0
Known Names
Molecular Properties
590.7
MW (Da)
6.00
ALogP
8
HBA
3
HBD
114.0
PSA (Ų)
0.20
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.37
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| PCSK9/LDLR CHEMBL4523996 | IC50 | 6.37 | 6.37 | 428.0 | 1 |
| Mast/stem cell growth factor receptor Kit CHEMBL1936 | IC50 | 5.71 | 5.71 | 1960.0 | 1 |
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 5.69 | 5.69 | 2040.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 243.0 | ng.hr.mL-1 | Mus musculus |
| AUC | 297.0 | ng.hr.mL-1 | Mus musculus |
| CL | 23.5 | mL.min-1.kg-1 | Mus musculus |
| MRT | 10.4 | hr | Mus musculus |
| T1/2 | 10.8 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| PCSK9/LDLR | IC50 | = | 428.0 | nM | 6.37 | Inhibition of recombinant human His-tagged PCSK9 interaction with recombinant LD... | 32051094 |
| Mast/stem cell growth factor receptor Kit | IC50 | = | 1960.0 | nM | 5.71 | Inhibition of recombinant human N-terminal GST-tagged c-Kit (544 to end residues... | 32051094 |
| Platelet-derived growth factor receptor beta | IC50 | = | 2040.0 | nM | 5.69 | Inhibition of recombinant human N-terminal GST-tagged PDGFRbeta cytoplasmic doma... | 32051094 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32051094 | 10.1016/j.bmc.2020.115344 | ADMET | 6 |
| 32051094 | 10.1016/j.bmc.2020.115344 | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 32051094 | 10.1016/j.bmc.2020.115344 | Platelet-derived growth factor receptor beta | 1 |
| 32051094 | 10.1016/j.bmc.2020.115344 | Tyrosine-protein kinase ABL1 | 1 |
| 32051094 | 10.1016/j.bmc.2020.115344 | Mast/stem cell growth factor receptor Kit | 1 |
| 32051094 | 10.1016/j.bmc.2020.115344 | PCSK9/LDLR | 1 |
Data from ChEMBL 36 via Core Engine