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Compound Detail

CHEMBL468654

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Cc1ccc2c([N+](=O)[O-])cc(C(=O)NC(C)c3ccc(F)cc3)c(O)c2n1

Basic Information

ChEMBL ID CHEMBL468654
Phase Preclinical
Structure Type MOL
InChI Key TTXYMUMLBYJTSF-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

369.4
MW (Da)
3.79
ALogP
5
HBA
2
HBD
105.4
PSA (Ų)
0.54
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H16FN3O4
MW 369.35
Aromatic Rings 3
Heavy Atoms 27
NP-Likeness -1.45

Activity Summary

IC50 2 meas. best 5.06

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Spinacia oleracea
CHEMBL612824
IC50 5.06 5.06 8700.0 1
Chlorella vulgaris
CHEMBL613342
IC50 4.36 4.36 43600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18342517 10.1016/j.bmc.2008.02.065 No relevant target 1
18342517 10.1016/j.bmc.2008.02.065 Spinacia oleracea 1
18342517 10.1016/j.bmc.2008.02.065 Chlorella vulgaris 1

Data from ChEMBL 36 via Core Engine