Compound Detail
CHEMBL472718
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL472718 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OXXMHBHCRXLDSD-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
329.4
MW (Da)
5.00
ALogP
2
HBA
2
HBD
32.3
PSA (Ų)
0.60
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA transporter 3 CHEMBL5205 | IC50 | 5.1 | 5.1 | 7943.3 | 1 |
| GABA transporter 2 CHEMBL4228 | IC50 | 4.75 | 4.75 | 17782.8 | 1 |
| GABA transporter 4 CHEMBL3699 | IC50 | 4.68 | 4.68 | 20893.0 | 1 |
| Sodium- and chloride-dependent GABA transporter 1 CHEMBL5445 | IC50 | 4.54 | 4.54 | 28840.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA transporter 3 | IC50 | = | 7943.28 | nM | 5.1 | Inhibition of [3H]GABA uptake at mouse GAT3 expressed in HEK cells | 18395300 |
| GABA transporter 2 | IC50 | = | 17782.79 | nM | 4.75 | Inhibition of [3H]GABA uptake at mouse GAT2 expressed in HEK cells | 18395300 |
| GABA transporter 4 | IC50 | = | 20892.96 | nM | 4.68 | Inhibition of [3H]GABA uptake at mouse GAT4 expressed in HEK cells | 18395300 |
| Sodium- and chloride-dependent GABA transporter 1 | IC50 | = | 28840.32 | nM | 4.54 | Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK cells | 18395300 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18395300 | 10.1016/j.ejmech.2008.01.005 | GABA transporter 4 | 1 |
| 18395300 | 10.1016/j.ejmech.2008.01.005 | GABA transporter 2 | 1 |
| 18395300 | 10.1016/j.ejmech.2008.01.005 | Sodium- and chloride-dependent GABA transporter 1 | 1 |
| 18395300 | 10.1016/j.ejmech.2008.01.005 | GABA transporter 3 | 1 |
Data from ChEMBL 36 via Core Engine