Compound Detail
CHEMBL4743439
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Basic Information
| ChEMBL ID | CHEMBL4743439 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZMRAZLUJHGBXRC-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
441.6
MW (Da)
4.27
ALogP
4
HBA
4
HBD
113.0
PSA (Ų)
0.25
QED
0
Ro5 Violations
14
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mus musculus CHEMBL375 | EC50 | 8.25 | 8.25 | 5.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mus musculus | EC50 | = | 5.6 | nM | 8.25 | Induction of lymphopenia in orally dosed Balb/c mouse assessed as reduction of c... | 28002964 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28002964 | 10.1021/acs.jmedchem.6b01433 | Cerebellum | 3 |
| 28002964 | 10.1021/acs.jmedchem.6b01433 | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine