Assay Detail
Functional
CHEMBL4719888
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of lymphopenia in orally dosed Balb/c mouse assessed as reduction of circulating lymphocytes measured after 24 hrs relative to control
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P Receptor Modulator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.94 | 8.25 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4743439 | — | — | 1 | 8.25 |
| CHEMBL3806205 | — | — | 1 | 8.10 |
| CHEMBL4762613 | — | — | 1 | 7.46 |
| CHEMBL3806158 | BMS-986104 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4743439 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL3806205 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL4762613 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3806158 | BMS-986104 | Activity | - | — | - |