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Compound Detail

CHEMBL4747667

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Cc1cnn(C[C@](C)(O)C(=O)Nc2ccc(C#N)c(C(F)(F)F)c2)c1

Basic Information

ChEMBL ID CHEMBL4747667
Phase Preclinical
Structure Type MOL
InChI Key YLAKUYJASUOHOV-HNNXBMFYSA-N
2
Targets
7
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

352.3
MW (Da)
2.47
ALogP
5
HBA
2
HBD
90.9
PSA (Ų)
0.88
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H15F3N4O2
MW 352.32
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -1.81

Activity Summary

Ki 4 meas. best 5.81
IC50 3 meas. best 5.09

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Androgen receptor
CHEMBL1871
Ki 5.81 5.81 1552.0 3
Androgen receptor
CHEMBL3072
Ki 5.81 5.81 1552.0 1
Androgen receptor
CHEMBL1871
IC50 5.09 5.09 8087.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
33095584 10.1021/acs.jmedchem.0c00943 Androgen receptor 2

Data from ChEMBL 36 via Core Engine