Compound Detail
CHEMBL4750281
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Basic Information
| ChEMBL ID | CHEMBL4750281 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IYVSSQRZIKZEKQ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
353.3
MW (Da)
1.31
ALogP
8
HBA
1
HBD
137.1
PSA (Ų)
0.77
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.93
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 CHEMBL3839 | IC50 | 5.93 | 5.93 | 1180.0 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 5.06 | 5.06 | 8700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 | IC50 | = | 1180.0 | nM | 5.93 | Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphoryl... | 32930584 |
| Fibroblast growth factor receptor 4 | IC50 | = | 8700.0 | nM | 5.06 | Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (u... | 32930584 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32930584 | 10.1021/acs.jmedchem.0c01019 | Fibroblast growth factor receptor 4 | 2 |
| 32930584 | 10.1021/acs.jmedchem.0c01019 | ADMET | 1 |
| 32930584 | 10.1021/acs.jmedchem.0c01019 | Huh-7 | 1 |
Data from ChEMBL 36 via Core Engine