Compound Detail
CHEMBL4763087
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Basic Information
| ChEMBL ID | CHEMBL4763087 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IBHOTNCJTRATHT-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
344.4
MW (Da)
2.54
ALogP
4
HBA
2
HBD
93.8
PSA (Ų)
0.60
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MAP kinase-interacting serine/threonine-protein kinase 2 CHEMBL4204 | IC50 | 6.47 | 6.47 | 340.0 | 1 |
| MAP kinase-interacting serine/threonine-protein kinase 1 CHEMBL4718 | IC50 | 6.06 | 6.06 | 878.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MAP kinase-interacting serine/threonine-protein kinase 2 | IC50 | = | 340.0 | nM | 6.47 | Inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 ... | 33303237 |
| MAP kinase-interacting serine/threonine-protein kinase 1 | IC50 | = | 878.0 | nM | 6.06 | Inhibition of recombinant human full-length N-terminal GST-fused MNK1 (1 to 424 ... | 33303237 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33303237 | 10.1016/j.ejmech.2020.113057 | MAP kinase-interacting serine/threonine-protein kinase 1 | 1 |
| 33303237 | 10.1016/j.ejmech.2020.113057 | MAP kinase-interacting serine/threonine-protein kinase 2 | 1 |
Data from ChEMBL 36 via Core Engine