Compound Detail
CHEMBL4782944
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4782944 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ADNJUAOLUJJJHY-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
243.3
MW (Da)
1.80
ALogP
3
HBA
2
HBD
81.0
PSA (Ų)
0.80
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| CDK8/Cyclin C CHEMBL3038474 | IC50 | 8.59 | 8.59 | 2.6 | 1 |
| Cyclin-C/Cyclin-dependent kinase 19 CHEMBL3883323 | IC50 | 7.92 | 7.92 | 11.9 | 1 |
| Serine/threonine-protein kinase haspin CHEMBL1075163 | IC50 | 7.42 | 7.42 | 38.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| CDK8/Cyclin C | IC50 | = | 2.59 | nM | 8.59 | CDK8/Cyclin C Binding Assay: The binding assay relies on the LanthaScreen Eu-Ki... | - |
| Cyclin-C/Cyclin-dependent kinase 19 | IC50 | = | 11.9 | nM | 7.92 | CDK19/Cyclin C Binding Assay: The binding assay relies on the LanthaScreen Eu-K... | - |
| Serine/threonine-protein kinase haspin | IC50 | = | 38.1 | nM | 7.42 | Haspin Kinase Assay: The kinase assay relies on ADP-GloKM biochemical kinase ass... | - |
Data from ChEMBL 36 via Core Engine