Compound Detail
CHEMBL4785298
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Basic Information
| ChEMBL ID | CHEMBL4785298 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YVLVNISRWNMKAN-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
411.5
MW (Da)
4.08
ALogP
6
HBA
3
HBD
94.8
PSA (Ų)
0.41
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK CHEMBL2599 | IC50 | 6.52 | 6.52 | 301.0 | 1 |
| Tyrosine-protein kinase BTK CHEMBL5251 | IC50 | 6.43 | 6.43 | 369.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK | IC50 | = | 301.0 | nM | 6.52 | Inhibition of SYK (unknown origin) using poly(Glu, Tyr) 4:1 as substrate incubat... | 32731189 |
| Tyrosine-protein kinase BTK | IC50 | = | 369.0 | nM | 6.43 | Inhibition of BTK (unknown origin) using poly(Glu, Tyr) 4:1 as substrate incubat... | 32731189 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32731189 | 10.1016/j.ejmech.2020.112636 | Tyrosine-protein kinase SYK | 2 |
| 32731189 | 10.1016/j.ejmech.2020.112636 | Tyrosine-protein kinase BTK | 2 |
Data from ChEMBL 36 via Core Engine