Compound Detail
CHEMBL4786846
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Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)NC4(Cc5ccccc5)COC4)cc32)c(C)c1NC(=O)CCl
Basic Information
| ChEMBL ID | CHEMBL4786846 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VMQSJVFQDTYPFW-NHDPSOOVSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
519.0
MW (Da)
4.04
ALogP
4
HBA
4
HBD
112.3
PSA (Ų)
0.28
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.02
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| G protein-coupled receptor kinase 5 CHEMBL5678 | IC50 | 7.02 | 7.02 | 95.0 | 1 |
| Beta-adrenergic receptor kinase 1 CHEMBL3711550 | IC50 | 4.82 | 4.82 | 15000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.16 | 4.16 | 69000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| G protein-coupled receptor kinase 5 | IC50 | = | 95.0 | nM | 7.02 | Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for ... | 33393767 |
| Beta-adrenergic receptor kinase 1 | IC50 | = | 15000.0 | nM | 4.82 | Inhibition of bovine GRK2 using porcine brain tubulin as substrate incubated for... | 33393767 |
| Unchecked | IC50 | = | 69000.0 | nM | 4.16 | Inhibition of PKA (unknown origin) incubated for 30 mins using REBtide substrate... | 33393767 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33393767 | 10.1021/acs.jmedchem.0c01522 | G protein-coupled receptor kinase 5 | 3 |
| 33393767 | 10.1021/acs.jmedchem.0c01522 | Unchecked | 2 |
| 33393767 | 10.1021/acs.jmedchem.0c01522 | Beta-adrenergic receptor kinase 1 | 1 |
Data from ChEMBL 36 via Core Engine