Compound Detail
CHEMBL4793814
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Basic Information
| ChEMBL ID | CHEMBL4793814 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KHWQLQMKSMNUBQ-JKSUJKDBSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
359.8
MW (Da)
2.75
ALogP
3
HBA
3
HBD
79.5
PSA (Ų)
0.78
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 9.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| N-formyl peptide receptor 2 CHEMBL4227 | EC50 | 9.04 | 9.04 | 0.9 | 1 |
| fMet-Leu-Phe receptor CHEMBL3359 | EC50 | 7.0 | 7.0 | 100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| N-formyl peptide receptor 2 | EC50 | = | 0.91 | nM | 9.04 | Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15... | 32407089 |
| fMet-Leu-Phe receptor | EC50 | = | 100.0 | nM | 7.0 | Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15... | 32407089 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32407089 | 10.1021/acs.jmedchem.9b02101 | N-formyl peptide receptor 2 | 1 |
| 32407089 | 10.1021/acs.jmedchem.9b02101 | fMet-Leu-Phe receptor | 1 |
| 32407089 | 10.1021/acs.jmedchem.9b02101 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine