Compound Detail
CHEMBL480298
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CCCNC(=O)c1cccc(Oc2cccc(-c3c(Cc4ccccc4)cnc4c(C(F)(F)F)cccc34)c2)c1
Basic Information
| ChEMBL ID | CHEMBL480298 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AJAGFKNPKFWBMC-UHFFFAOYSA-N |
4
Targets
6
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
540.6
MW (Da)
8.44
ALogP
3
HBA
1
HBD
51.2
PSA (Ų)
0.21
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 6.38
IC50 2 meas. best 8.07
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Oxysterols receptor LXR-beta CHEMBL4093 | IC50 | 8.07 | 8.07 | 8.5 | 1 |
| Oxysterols receptor LXR-alpha CHEMBL2808 | IC50 | 7.04 | 7.04 | 91.0 | 1 |
| J774 CHEMBL614123 | EC50 | 6.38 | 6.38 | 420.0 | 1 |
| Oxysterols receptor LXR-beta CHEMBL4093 | EC50 | 5.82 | 5.82 | 1525.0 | 1 |
| Oxysterols receptor LXR-alpha CHEMBL2808 | EC50 | 5.57 | 5.57 | 2709.0 | 1 |
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | EC50 | 5.42 | 5.42 | 3800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Oxysterols receptor LXR-beta | IC50 | = | 8.5 | nM | 8.07 | Displacement of [3H]T0901317 from human recombinant N-terminal biotinylated tagg... | 19162487 |
| Oxysterols receptor LXR-alpha | IC50 | = | 91.0 | nM | 7.04 | Displacement of [3H]T0901317 from human recombinant N-terminal biotinylated tagg... | 19162487 |
| J774 | EC50 | = | 420.0 | nM | 6.38 | Induction of ABCA1 mRNA expression in mouse J774 cells | 19162487 |
| Oxysterols receptor LXR-beta | EC50 | = | 1525.0 | nM | 5.82 | Agonist activity at human LXRbeta ligand binding domain expressed in human HuH7 ... | 19162487 |
| Oxysterols receptor LXR-alpha | EC50 | = | 2709.0 | nM | 5.57 | Agonist activity at human LXRalpha ligand binding domain expressed in human HuH7... | 19162487 |
| Peroxisome proliferator-activated receptor gamma | EC50 | = | 3800.0 | nM | 5.42 | Agonist activity at PPARgamma in transiently transfected cells by Gal4 transacti... | 19162487 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19162487 | 10.1016/j.bmc.2008.12.048 | Oxysterols receptor LXR-beta | 3 |
| 19162487 | 10.1016/j.bmc.2008.12.048 | Oxysterols receptor LXR-alpha | 3 |
| 19162487 | 10.1016/j.bmc.2008.12.048 | J774 | 2 |
| 19162487 | 10.1016/j.bmc.2008.12.048 | Peroxisome proliferator-activated receptor gamma | 2 |
| 19162487 | 10.1016/j.bmc.2008.12.048 | Peroxisome proliferator-activated receptor alpha | 1 |
| 19162487 | 10.1016/j.bmc.2008.12.048 | Peroxisome proliferator-activated receptor delta | 1 |
Data from ChEMBL 36 via Core Engine