Compound Detail
CHEMBL481577
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL481577 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YEFGGTAFRZXAOF-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
291.7
MW (Da)
3.70
ALogP
3
HBA
2
HBD
58.6
PSA (Ų)
0.84
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.42
IC50 1 meas. best 5.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Calcium-activated potassium channel subunit alpha-1 CHEMBL4304 | IC50 | 5.51 | 5.51 | 3090.3 | 1 |
| Endoribonuclease toxin MazF CHEMBL1795096 | EC50 | 4.42 | 4.42 | 38000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Calcium-activated potassium channel subunit alpha-1 | IC50 | = | 3090.3 | nM | 5.51 | Activation of BK channel-mediated vasorelaxation activity assessed as reduction ... | 19026552 |
| Endoribonuclease toxin MazF | EC50 | = | 38000.0 | nM | 4.42 | PUBCHEM_BIOASSAY: Dose response confirmation uHTS hits for MazEF TA System activ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23707646 | 10.1016/j.bmc.2013.05.003 | Calcium-activated potassium channel subunit alpha-1 | 5 |
| 23707646 | 10.1016/j.bmc.2013.05.003 | Calcium-activated potassium channel alpha/beta 1 | 4 |
| 19026552 | 10.1016/j.bmc.2008.10.068 | Calcium-activated potassium channel subunit alpha-1 | 1 |
Data from ChEMBL 36 via Core Engine