Compound Detail
CHEMBL4849569
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Basic Information
| ChEMBL ID | CHEMBL4849569 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DUWRZIFULVNPGV-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
385.9
MW (Da)
4.43
ALogP
6
HBA
0
HBD
57.0
PSA (Ų)
0.52
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proteinase-activated receptor 4 CHEMBL4691 | IC50 | 8.17 | 7.785 | 6.8 | 2 |
| Proteinase-activated receptor 4 CHEMBL4879420 | IC50 | 6.8 | 6.8 | 160.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proteinase-activated receptor 4 | IC50 | = | 6.8 | nM | 8.17 | Antagonist activity at human PAR4 expressed in Ga15-HEK293 cells assessed as red... | 34391031 |
| Proteinase-activated receptor 4 | IC50 | = | 40.0 | nM | 7.4 | Antagonist activity at PAR4 in human platelet-rich plasma assessed as inhibition... | 34391031 |
| Proteinase-activated receptor 4 | IC50 | = | 160.0 | nM | 6.8 | Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibi... | 34391031 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34391031 | 10.1016/j.ejmech.2021.113764 | Proteinase-activated receptor 4 | 4 |
| 34391031 | 10.1016/j.ejmech.2021.113764 | Proteinase-activated receptor 1 | 1 |
| 34391031 | 10.1016/j.ejmech.2021.113764 | Proteinase-activated receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine