Compound Detail
CHEMBL4854645
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COc1ncc2cc1NS(=O)(=O)c1ccc(F)c(c1)C(=O)NCc1ccc(s1)-c1ncnc3cc-2sc13
Basic Information
| ChEMBL ID | CHEMBL4854645 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IICNWQTVBNJGKW-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
553.6
MW (Da)
4.67
ALogP
9
HBA
2
HBD
123.2
PSA (Ų)
0.31
QED
1
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | IC50 | 8.2 | 8.2 | 6.3 | 1 |
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | IC50 | 7.84 | 7.84 | 14.6 | 1 |
| Serine/threonine-protein kinase mTOR CHEMBL2842 | IC50 | 5.68 | 5.68 | 2100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 6.34 | nM | 8.2 | Inhibition of PI3Kalpha (unknown origin) by ADP-Glo assay | 34795869 |
| Serine/threonine-protein kinase pim-1 | IC50 | = | 14.6 | nM | 7.84 | Inhibition of human PIM1 using ARKRRRHPSGPPTA as substrate measured after 1.5 hr... | 34795869 |
| Serine/threonine-protein kinase mTOR | IC50 | = | 2100.0 | nM | 5.68 | Inhibition of mTOR (unknown origin) by LanthaScreen assay | 34795869 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34795869 | 10.1021/acsmedchemlett.1c00412 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 34795869 | 10.1021/acsmedchemlett.1c00412 | Serine/threonine-protein kinase mTOR | 1 |
| 34795869 | 10.1021/acsmedchemlett.1c00412 | Serine/threonine-protein kinase pim-1 | 1 |
Data from ChEMBL 36 via Core Engine