Assay Detail
Binding
CHEMBL4845571
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Inhibition of mTOR (unknown origin) by LanthaScreen assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.50 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1236962 | OMIPALISIB | 2.0 | 1 | 8.90 |
| CHEMBL4878958 | — | — | 1 | 7.13 |
| CHEMBL4851911 | — | — | 1 | 7.09 |
| CHEMBL4860369 | — | — | 1 | 6.86 |
| CHEMBL4868512 | — | — | 1 | 6.76 |
| CHEMBL4876895 | — | — | 1 | 6.71 |
| CHEMBL4874628 | — | — | 1 | 6.22 |
| CHEMBL4869487 | — | — | 1 | 5.69 |
| CHEMBL4854645 | — | — | 1 | 5.68 |
| CHEMBL4866896 | — | — | 1 | 5.25 |
| CHEMBL4862404 | — | — | 1 | 5.24 |
| CHEMBL4869696 | — | — | 1 | - |
| CHEMBL4851433 | — | — | 1 | - |
| CHEMBL4871634 | — | — | 1 | - |
| CHEMBL4859036 | — | — | 1 | - |
| CHEMBL4857792 | — | — | 1 | - |
| CHEMBL4870601 | — | — | 1 | - |
| CHEMBL4854392 | — | — | 1 | - |
| CHEMBL4857726 | — | — | 1 | - |
| CHEMBL4868086 | — | — | 1 | - |
| CHEMBL4854225 | — | — | 1 | - |
| CHEMBL4866710 | — | — | 1 | - |
| CHEMBL4860117 | — | — | 1 | - |
| CHEMBL4876693 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1236962 | OMIPALISIB | IC50 | = | 1.25 | nM | 8.90 |
| CHEMBL4878958 | — | IC50 | = | 74.53 | nM | 7.13 |
| CHEMBL4851911 | — | IC50 | = | 80.88 | nM | 7.09 |
| CHEMBL4860369 | — | IC50 | = | 138.17 | nM | 6.86 |
| CHEMBL4868512 | — | IC50 | = | 175.33 | nM | 6.76 |
| CHEMBL4876895 | — | IC50 | = | 197.33 | nM | 6.71 |
| CHEMBL4874628 | — | IC50 | = | 604.0 | nM | 6.22 |
| CHEMBL4869487 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL4854645 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4866896 | — | IC50 | = | 5570.0 | nM | 5.25 |
| CHEMBL4862404 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4869696 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4851433 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4871634 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4859036 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4857792 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4870601 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4854392 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4857726 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4868086 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4854225 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4866710 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4860117 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4876693 | — | IC50 | > | 1000.0 | nM | - |