Compound Detail
CHEMBL4868512
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COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cncc(c1)-c1ncnc3c(C)c-2sc13
Basic Information
| ChEMBL ID | CHEMBL4868512 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CWLUZOJADRKJSM-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
544.6
MW (Da)
4.18
ALogP
9
HBA
2
HBD
136.1
PSA (Ų)
0.32
QED
1
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | IC50 | 7.72 | 7.72 | 19.0 | 1 |
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | IC50 | 7.37 | 7.37 | 42.9 | 1 |
| Serine/threonine-protein kinase mTOR CHEMBL2842 | IC50 | 6.76 | 6.76 | 175.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 19.03 | nM | 7.72 | Inhibition of PI3Kalpha (unknown origin) by ADP-Glo assay | 34795869 |
| Serine/threonine-protein kinase pim-1 | IC50 | = | 42.87 | nM | 7.37 | Inhibition of human PIM1 using ARKRRRHPSGPPTA as substrate measured after 1.5 hr... | 34795869 |
| Serine/threonine-protein kinase mTOR | IC50 | = | 175.33 | nM | 6.76 | Inhibition of mTOR (unknown origin) by LanthaScreen assay | 34795869 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34795869 | 10.1021/acsmedchemlett.1c00412 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 34795869 | 10.1021/acsmedchemlett.1c00412 | Serine/threonine-protein kinase mTOR | 1 |
| 34795869 | 10.1021/acsmedchemlett.1c00412 | Serine/threonine-protein kinase pim-1 | 1 |
Data from ChEMBL 36 via Core Engine