Compound Detail
CHEMBL4854830
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Basic Information
| ChEMBL ID | CHEMBL4854830 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OJHBHYPBUXLUGB-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
374.4
MW (Da)
2.81
ALogP
5
HBA
2
HBD
91.9
PSA (Ų)
0.78
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Apelin receptor CHEMBL1628481 | EC50 | 5.96 | 5.96 | 1100.0 | 1 |
| Apelin receptor CHEMBL2398 | EC50 | 5.92 | 5.92 | 1200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Apelin receptor | EC50 | = | 1100.0 | nM | 5.96 | Agonist activity at human APJ receptor expressed in HEK293T cells assessed as co... | 34795866 |
| Apelin receptor | EC50 | = | 1200.0 | nM | 5.92 | Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as comp... | 34795866 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34795866 | 10.1021/acsmedchemlett.1c00385 | Apelin receptor | 2 |
Data from ChEMBL 36 via Core Engine