Compound Detail
CHEMBL4863816
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CC(C)C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)CSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2ccc(C(N)=O)cc2)NC(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC1=O
Basic Information
| ChEMBL ID | CHEMBL4863816 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PIGGMXRCAYMJCI-YFWBWJTRSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1106.4
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nicotinamide N-methyltransferase CHEMBL4295666 | IC50 | 7.24 | 7.24 | 58.0 | 1 |
| Nicotinamide N-methyltransferase CHEMBL2346486 | IC50 | 7.21 | 7.21 | 61.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nicotinamide N-methyltransferase | IC50 | = | 58.0 | nM | 7.24 | Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate ass... | 34267879 |
| Nicotinamide N-methyltransferase | IC50 | = | 61.0 | nM | 7.21 | Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate ass... | 34267879 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34267879 | 10.1021/acsmedchemlett.1c00134 | Nicotinamide N-methyltransferase | 2 |
Data from ChEMBL 36 via Core Engine