Compound Detail
CHEMBL491405
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL491405 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JTQIPRFASTWFSP-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
344.7
MW (Da)
3.28
ALogP
4
HBA
1
HBD
68.0
PSA (Ų)
0.61
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | Ki | 7.44 | 7.44 | 36.5 | 1 |
| Serine/threonine-protein kinase pim-2 CHEMBL4523 | Ki | 6.25 | 6.25 | 558.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | Ki | = | 36.5 | nM | 7.44 | Inhibition of Pim1 | 18790640 |
| Serine/threonine-protein kinase pim-2 | Ki | = | 558.0 | nM | 6.25 | Inhibition of Pim2 | 18790640 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18790640 | 10.1016/j.bmcl.2008.08.079 | Serine/threonine-protein kinase pim-1 | 1 |
| 18790640 | 10.1016/j.bmcl.2008.08.079 | Serine/threonine-protein kinase pim-2 | 1 |
Data from ChEMBL 36 via Core Engine