Assay Detail
Binding
CHEMBL994191
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Pim2
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Serine/threonine-protein kinase pim-2 (CHEMBL4523) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.87 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL523823 | — | — | 1 | 7.36 |
| CHEMBL509801 | — | — | 1 | 7.20 |
| CHEMBL492223 | — | — | 1 | 6.78 |
| CHEMBL468280 | — | — | 1 | 6.76 |
| CHEMBL491405 | — | — | 1 | 6.25 |
| CHEMBL489783 | — | — | 1 | - |
| CHEMBL489784 | — | — | 1 | - |
| CHEMBL522266 | — | — | 1 | - |
| CHEMBL500183 | — | — | 1 | - |
| CHEMBL454241 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL523823 | — | Ki | = | 43.5 | nM | 7.36 |
| CHEMBL509801 | — | Ki | = | 62.8 | nM | 7.20 |
| CHEMBL492223 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL468280 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL491405 | — | Ki | = | 558.0 | nM | 6.25 |
| CHEMBL489783 | — | Ki | > | 1424.0 | nM | - |
| CHEMBL489784 | — | Ki | > | 1424.0 | nM | - |
| CHEMBL522266 | — | Ki | > | 1424.0 | nM | - |
| CHEMBL500183 | — | Ki | > | 1424.0 | nM | - |
| CHEMBL454241 | — | Ki | > | 1424.0 | nM | - |