Compound Detail
CHEMBL509801
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Basic Information
| ChEMBL ID | CHEMBL509801 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WDOAVCPYTBBYJE-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
296.7
MW (Da)
2.81
ALogP
4
HBA
1
HBD
68.0
PSA (Ų)
0.75
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.91
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | Ki | 7.91 | 7.91 | 12.3 | 1 |
| Serine/threonine-protein kinase pim-2 CHEMBL4523 | Ki | 7.2 | 7.2 | 62.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | Ki | = | 12.3 | nM | 7.91 | Inhibition of Pim1 | 18790640 |
| Serine/threonine-protein kinase pim-2 | Ki | = | 62.8 | nM | 7.2 | Inhibition of Pim2 | 18790640 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18790640 | 10.1016/j.bmcl.2008.08.079 | Serine/threonine-protein kinase pim-1 | 1 |
| 18790640 | 10.1016/j.bmcl.2008.08.079 | Serine/threonine-protein kinase pim-2 | 1 |
Data from ChEMBL 36 via Core Engine